Increases in inflammatory and CD14^dim/CD16^pos/CD45^pos patrolling monocytes in sepsis: correlation with final outcome.

ABSTRACT:

Background

Evidence on the changes in the absolute counts of monocyte subpopulations in sepsis is missing.

Methods

Firstly, absolute counts of circulating CD14^pos/HLA-DR^pos/CD45^pos monocytes were measured by flow cytometry in 70 patients with Gram-negative sepsis and in 10 healthy volunteers. In the second phase, immunophenotyping was performed and the absolute count of circulating inflammatory monocytes and of circulating CD14^dim/CD16^pos/CD45^pos patrolling monocytes were measured in another 55 patients and 10 healthy volunteers. Measurements were repeated on days 3, 7, and 10. Results were correlated with survival after 28 days.

Results

Greater numbers of CD14^pos/HLA-DR^pos/CD45

SUBMITTER: Gainaru G 

PROVIDER: S-EPMC5834896 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature