CAR-T Cells: A Systematic Review and Mixed Methods Analysis of the Clinical Trial Landscape.

ABSTRACT: CAR-T cells are a promising new therapy that offer significant advantages compared with conventional immunotherapies. This systematic review and clinical trial landscape identifies and critiques published CAR-T cell clinical trials and examines the critical factors required to enable CAR-T cells to become a standard therapy. A review of the literature was conducted to identify suitable studies from the MEDLINE and Ovid bibliographic databases. The literature and database searches identified 20 studies for inclusion. The average number of participants per clinical trial examined was 11 patients. All studies included in this systematic review investigated CAR-T cells and were prospective, uncontrolled clinical studies. Leukemia is the most common cancer subtype and accounts for 57.4% (n = 12

SUBMITTER: Pettitt D 

PROVIDER: S-EPMC5835018 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature