Decrease of perforin positive CD3⁺γδ-T cells in patients with obstructive sleep disordered breathing.

ABSTRACT:

Introduction

Sleep related breathing disorders (SRBD) cause sleep fragmentation, intermittent hypoxia or a combination of both leading to homeostasis perturbations, including in the immune system. We investigated whether SRBD patients with or without intermittent hypoxia show substantial differences in perforin and granzyme-B positive peripheral blood lymphocytes.

Methods

A total of 87 subjects were included and distributed as follows: 24 controls (C), 19 patients with respiratory effort related arousals due to increased upper airway resistance (UAR) without hypoxic events, 24 obese patients with obstructive sleep apnea (OSA) (oOSA), and 20 without obesity (noOSA). After polysomnographic recording, we analyzed in fasting blood samples routine hematologic and biochemical para

SUBMITTER: Staats R 

PROVIDER: S-EPMC5835055 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature