Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells.

ABSTRACT: Immune checkpoint inhibition has been shown to successfully reactivate endogenous T cell responses directed against tumor-associated antigens, resulting in significantly prolonged overall survival in patients with various tumor entities. For malignancies with low endogenous immune responses, this approach has not shown a clear clinical benefit so far. Therapeutic vaccination, particularly dendritic cell (DC) vaccination, is a strategy to induce T cell responses. Interaction of DCs and T cells is dependent on receptor-ligand interactions of various immune checkpoints. In this study, we analyzed the influence of blocking antibodies targeting programmed cell death protein 1 (PD-1), HVEM, CD244, TIM-3, and lymphocyte activation gene 3 (LAG-3) on the proliferation and cytokine secretion of T ce

SUBMITTER: Lichtenegger FS 

PROVIDER: S-EPMC5835137 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature