Micro-Nanostructures of Cellulose-Collagen for Critical Sized Bone Defect Healing.

ABSTRACT: Bone tissue engineering strategies utilize biodegradable polymeric matrices alone or in combination with cells and factors to provide mechanical support to bone, while promoting cell proliferation, differentiation, and tissue ingrowth. The performance of mechanically competent, micro-nanostructured polymeric matrices, in combination with bone marrow stromal cells (BMSCs), is evaluated in a critical sized bone defect. Cellulose acetate (CA) is used to fabricate a porous microstructured matrix. Type I collagen is then allowed to self-assemble on these microstructures to create a natural polymer-based, micro-nanostructured matrix (CAc). Poly (lactic-co-glycolic acid) matrices with identical microstructures serve as controls. Significantly higher number of implanted host cells are distributed

SUBMITTER: Aravamudhan A 

PROVIDER: S-EPMC5835266 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature