Hydrogen peroxide production by lactobacilli promotes epithelial restitution during colitis.

ABSTRACT: Inflammatory bowel disease (IBD) is a multifactorial chronic inflammatory disease of the gastrointestinal tract, characterized by cycles of acute flares, recovery and remission phases. Treatments for accelerating tissue restitution and prolonging remission are scarce, but altering the microbiota composition to promote intestinal homeostasis is considered a safe, economic and promising approach. Although probiotic bacteria have not yet fulfilled fully their promise in clinical trials, understanding the mechanism of how they exert beneficial effects will permit devising improved therapeutic strategies. Here we probe if one of the defining features of lactobacilli, the ability to generate nanomolar H₂O₂, contributes to their beneficial role in colitis. H₂O

SUBMITTER: Singh AK 

PROVIDER: S-EPMC5835490 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature