Dopaminergic and Opioid Pathways Associated with Impulse Control Disorders in Parkinson's Disease.

ABSTRACT:

Introduction

Impulse control disorders (ICDs) are frequent non-motor symptoms in Parkinson's disease (PD), with potential negative effects on the quality of life and social functioning. ICDs are closely associated with dopaminergic therapy, and genetic polymorphisms in several neurotransmitter pathways may increase the risk of addictive behaviors in PD. However, clinical differentiation between patients at risk and patients without risk of ICDs is still troublesome. The aim of this study was to investigate if genetic polymorphisms across several neurotransmitter pathways were associated with ICD status in patients with PD.

Methods

Whole-exome sequencing data were available for 119 eligible PD patients from the Norwegian ParkWest study. All participants underwent comprehensiv

SUBMITTER: Erga AH 

PROVIDER: S-EPMC5835501 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature