Genetic Variation in the Dopamine System Influences Intervention Outcome in Children with Cerebral Palsy.

ABSTRACT:

Background

There is large variation in treatment responses in children with cerebral palsy. Experimental and clinical results suggest that dopamine neurotransmission and brain-derived neurotrophic factor (BDNF) signalling are involved in motor learning and plasticity, which are key factors in modern habilitation success. We examined whether naturally occurring variations in dopamine and BDNF genes influenced the treatment outcomes.

Methods

Thirty-three children (18-60months of age) with spastic unilateral cerebral palsy were enrolled in the study. Each child had participated in a training programme consisting of active training of the involved hand for 2h every day during a 2-month training period. The training outcome was measured using Assisting Hand Assessment before and

SUBMITTER: Diaz Heijtz R 

PROVIDER: S-EPMC5835543 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature