Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene-Gene Interactions.

ABSTRACT: Hypertension is a leading cause of cardiovascular mortality, but only about half of patients on antihypertensive therapy achieve blood pressure control. Preeclampsia is defined as pregnancy-induced hypertension and proteinuria, and is associated with increased maternal and perinatal mortality and morbidity. Similarly, a large number of patients with preeclampsia are non-responsive to antihypertensive therapy. Pharmacogenomics may help to guide the personalized treatment for non-responsive hypertensive patients. There is evidence for the association of genetic variants with variable response to the most commonly used antihypertensive drugs. However, further replication is needed to confirm these associations in different populations. The failure to replicate findings from single-locus assoc

SUBMITTER: Luizon MR 

PROVIDER: S-EPMC5835759 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature