Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells.

ABSTRACT: Dendritic cells (DCs) are key directors of tolerogenic and immunogenic immune responses. During the steady state, DCs maintain T cell tolerance to self-antigens by multiple mechanisms including inducing anergy, deletion, and Treg activity. All of these mechanisms help to prevent autoimmune diseases or other hyperreactivities. Different DC subsets contribute to pathogen recognition by expression of different subsets of pattern recognition receptors, including Toll-like receptors or C-type lectins. In addition to the triggering of immune responses in infected hosts, most pathogens have evolved mechanisms for evasion of targeted responses. One such strategy is characterized by adopting the host's T cell tolerance mechanisms. Understanding these tolerogenic mechanisms is of utmost importance f

SUBMITTER: Vendelova E 

PROVIDER: S-EPMC5835767 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature