Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance.

ABSTRACT: Caseinolytic peptidase P (ClpP) is a mammalian quality control protease that is proposed to play an important role in the initiation of the mitochondrial unfolded protein response (UPR^mt), a retrograde signaling response that helps to maintain mitochondrial protein homeostasis. Mitochondrial dysfunction is associated with the development of metabolic disorders, and to understand the effect of a defective UPR^mt on metabolism, ClpP knockout (ClpP^-/-) mice were analyzed. ClpP^-/- mice fed ad libitum have reduced adiposity and paradoxically improved insulin sensitivity. Absence of ClpP increased whole-body energy expenditure and markers of mitochondrial biogenesis are selectively up-regulated in the white adipose tissue (WAT) of <

SUBMITTER: Bhaskaran S 

PROVIDER: S-EPMC5836096 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature