Toxoplasma gondii disrupts β1 integrin signaling and focal adhesion formation during monocyte hypermotility.

ABSTRACT: The motility of blood monocytes is orchestrated by the activity of cell-surface integrins, which translate extracellular signals into cytoskeletal changes to mediate adhesion and migration. Toxoplasma gondii is an intracellular parasite that infects migratory cells and enhances their motility, but the mechanisms underlying T. gondii-induced hypermotility are incompletely understood. We investigated the molecular basis for the hypermotility of primary human peripheral blood monocytes and THP-1 cells infected with T. gondii Compared with uninfected monocytes, T. gondii infection of monocytes reduced cell spreading and the number of activated β1 integrin clusters in contact with fibronectin during settling, an effect not observed in monocytes treated with lipopolys

SUBMITTER: Cook JH 

PROVIDER: S-EPMC5836128 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature