Long-Lasting Response to Trabectedin in a Patient with Metastatic Uterine Leiomyosarcoma: A Case Report.

ABSTRACT:

Background

Uterine leiomyosarcoma (uLMS) is a rare tumor that accounts for 1% of all uterine malignancies. In spite of adequate surgical resection of uLMS, even in the early stage, patients remain at high risk for local and distant recurrence. Therefore, the treatment of advanced uLMS represents a considerable challenge.

Methods

We report the case of a 47-year-old woman who presented with uLMS with abnormal vaginal bleeding.

Results

The patient underwent a total hysterectomy and bilateral adnexectomy, which was followed by 1 year progression-free survival without adjuvant therapy. Thereafter, new lung metastases and local progression at the vaginal stump were observed. Chemotherapy with ifosfamide and doxorubicin was administered. However, after 4 cycles, a CT scan re

SUBMITTER: Nteli VA 

PROVIDER: S-EPMC5836215 | biostudies-literature | 2018 Jan-Apr

REPOSITORIES: biostudies-literature