Lysine Succinylation Contributes to Aflatoxin Production and Pathogenicity in Aspergillus flavus.

ABSTRACT: Aspergillus flavus (A. flavus) is a ubiquitous saprophytic and pathogenic fungus that produces the aflatoxin carcinogen, and A. flavus can have tremendous economic and health impacts worldwide. Increasing evidence demonstrates that lysine succinylation plays an important regulatory role in metabolic processes in both bacterial and human cells. However, little is known about the extent and function of lysine succinylation in A. flavus Here, we performed a global succinylome analysis of A. flavus using high accuracy nano-LC-MS/MS in combination with the enrichment of succinylated peptides from digested cell lysates and subsequent peptide identification. In total, 985 succinylation sites on 349 succinylated proteins were identified in this pathogen. Bioinfor

SUBMITTER: Ren S 

PROVIDER: S-EPMC5836371 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature