Improved adherence adjustment in the Coronary Drug Project.

ABSTRACT:

Background

The survival difference between adherers and non-adherers to placebo in the Coronary Drug Project has been used to support the thesis that adherence adjustment in randomized trials is not generally possible and, therefore, that only intention-to-treat analyses should be trusted. We previously demonstrated that adherence adjustment can be validly conducted in the Coronary Drug Project using a simplistic approach. Here, we re-analyze the data using an approach that takes full advantage of recent methodological developments.

Methods

We used inverse-probability weighted hazards models to estimate the 5-year survival and mortality risk when individuals in the placebo arm of the Coronary Drug Project adhere to at least 80% of the drug continuously or never during the 5-

SUBMITTER: Murray EJ 

PROVIDER: S-EPMC5836455 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature