Genomics of cellular proliferation in periodic environmental fluctuations.

ABSTRACT: Living systems control cell growth dynamically by processing information from their environment. Although responses to a single environmental change have been intensively studied, little is known about how cells react to fluctuating conditions. Here, we address this question at the genomic scale by measuring the relative proliferation rate (fitness) of 3,568 yeast gene deletion mutants in out-of-equilibrium conditions: periodic oscillations between two environmental conditions. In periodic salt stress, fitness and its genetic variance largely depended on the oscillating period. Surprisingly, dozens of mutants displayed pronounced hyperproliferation under short stress periods, revealing unexpected controllers of growth under fast dynamics. We validated the implication of the high-affinity c

SUBMITTER: Salignon J 

PROVIDER: S-EPMC5836541 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature