Excretion of Avenanthramides, Phenolic Acids and their Major Metabolites Following Intake of Oat Bran.

ABSTRACT:

Scope

Wholegrain has been associated with reduced chronic disease mortality, with oat intake particularly notable for lowering blood cholesterol and glycemia. To better understand the complex nutrient profile of oats, we studied urinary excretion of phenolic acids and avenanthramides after ingestion of oat bran in humans.

Methods and results

After a 2-d (poly)phenol-low diet, seven healthy men provided urine 12 h before and 48 h after consuming 60 g oat bran (7.8 μmol avenanthramides, 139.2 μmol phenolic acids) or a phenolic-low (traces of phenolics) control in a crossover design. Analysis by ultra-high performance liquid chromatography (UPLC)-MS/MS showed that oat bran intake resulted in an elevation in urinary excretion of 30 phenolics relative to the control, suggesting t

SUBMITTER: Schar MY 

PROVIDER: S-EPMC5836716 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature