Resting-state brain function in schizophrenia and psychotic bipolar probands and their first-degree relatives.

ABSTRACT:

Background

Schizophrenia (SCZ) and psychotic bipolar disorder (PBD) share considerable overlap in clinical features, genetic risk factors and co-occurrence among relatives. The common and unique functional cerebral deficits in these disorders, and in unaffected relatives, remain to be identified.

Method

A total of 59 healthy controls, 37 SCZ and 57 PBD probands and their unaffected first-degree relatives (38 and 28, respectively) were studied using resting-state functional magnetic resonance imaging (rfMRI). Regional cerebral function was evaluated by measuring the amplitude of low-frequency fluctuations (ALFF). Areas with ALFF alterations were used as seeds in whole-brain functional connectivity analysis. We then tested whether abnormalities identified in probands were pres

SUBMITTER: Lui S 

PROVIDER: S-EPMC5836742 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature