Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations.

ABSTRACT: African-American men have the highest incidence of and mortality from prostate cancer. Whether a biological basis exists for this disparity remains unclear. Exome sequencing (n = 102) and targeted validation (n = 90) of localized primary hormone-naïve prostate cancer in African-American men identified several gene mutations not previously observed in this context, including recurrent loss-of-function mutations in ERF, an ETS transcriptional repressor, in 5% of cases. Analysis of existing prostate cancer cohorts revealed ERF deletions in 3% of primary prostate cancers and mutations or deletions in ERF in 3% to 5% of lethal castration-resistant prostate cancers. Knockdown of ERF confers increased anchorage-independent growth and generates a gene expr

SUBMITTER: Huang FW 

PROVIDER: S-EPMC5836784 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature