Neck recurrence in clinically node-negative oral cancer: 27-year experience at a single institution.

ABSTRACT:

Objectives

Neck failure in patients with oral squamous cell carcinoma (OSCC) carries a poor outcome, yet the management of patients who initially present with clinically node-negative (cN0) neck is not clearly defined.

Patients and methods

Retrospective review of patients with cN0 OSCC treated at Memorial Sloan Kettering Cancer Center from 1985 to 2012, focusing on rate, pattern and predictors of neck failure, salvage treatment, and survival outcomes.

Results

Of 1,302 patients, 806 (62%) underwent elective neck dissection (END) and 496 (38%) had observation. 190 patients (15%) developed neck recurrence. Median follow-up was 58.5 months (range 1-343); 5-year neck recurrence-free survival (NRFS) was 85% and 80% for the END and observation group respectively (p = .06). P

SUBMITTER: Mizrachi A 

PROVIDER: S-EPMC5836807 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature