Consequences of early life stress on genomic landscape of H3K4me3 in prefrontal cortex of adult mice.

ABSTRACT:

Background

Maternal separation models in rodents are widely used to establish molecular mechanisms underlying prolonged effects of early life adversity on neurobiological and behavioral outcomes in adulthood. However, global epigenetic signatures following early life stress in these models remain unclear.

Results

In this study, we carried out a ChIP-seq analysis of H3K4 trimethylation profile in the prefrontal cortex of adult male mice with a history of early life stress. Two types of stress were used: prolonged separation of pups from their mothers (for 3 h once a day, maternal separation, MS) and brief separation (for 15 min once a day, handling, HD). Adult offspring in the MS group demonstrated reduced locomotor activity in the open field test accompanied by reduced explo

SUBMITTER: Ershov NI 

PROVIDER: S-EPMC5836825 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature