Ursodeoxycholic acid: Effects on hepatic unfolded protein response, apoptosis and oxidative stress in morbidly obese patients.

ABSTRACT:

Background & aims

Ursodeoxycholic acid (UDCA) is a secondary hydrophilic bile acid (BA) used as therapy for a range of hepatobiliary diseases. Its efficacy in non-alcoholic fatty liver disease (NAFLD) is still under debate. Here, we aimed to decipher molecular mechanisms of UDCA in regulating endoplasmic reticulum (ER) homeostasis, apoptosis and oxidative stress in morbidly obese patients.

Methods

In this randomized controlled pharmacodynamic study, liver and serum samples from 40 well-matched morbidly obese NAFLD-patients were analysed. Patients received UDCA (20 mg/kg/d) or no treatment 3 weeks before samples were obtained during bariatric surgery.

Results

Patients treated with UDCA displayed higher scoring of steatosis (S), activity (A) and fibrosis (F), the so cal

SUBMITTER: Mueller M 

PROVIDER: S-EPMC5836915 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature