Template-based quaternary structure prediction of proteins using enhanced profile-profile alignments.

ABSTRACT: Proteins often exist as their multimeric forms when they function as so-called biological assemblies consisting of the specific number and arrangement of protein subunits. Consequently, elucidating biological assemblies is necessary to improve understanding of protein function. Template-Based Modeling (TBM), based on known protein structures, has been used widely for protein structure prediction. Actually, TBM has become an increasingly useful approach in recent years because of the increased amounts of information related to protein amino acid sequences and three-dimensional structures. An apparently similar situation exists for biological assembly structure prediction as protein complex structures in the PDB increase, although the inference of biological assemblies is not a trivial task.

SUBMITTER: Nakamura T 

PROVIDER: S-EPMC5836938 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature