Modelling time varying heterogeneity in recurrent infection processes: an application to serological data.

ABSTRACT: Frailty models are often used in survival analysis to model multivariate time-to-event data. In infectious disease epidemiology, frailty models have been proposed to model heterogeneity in the acquisition of infection and to accommodate association in the occurrence of multiple types of infection. Although traditional frailty models rely on the assumption of lifelong immunity after recovery, refinements have been made to account for reinfections with the same pathogen. Recently, Abrams and Hens quantified the effect of misspecifying the underlying infection process on the basic and effective reproduction number in the context of bivariate current status data on parvovirus B19 and varicella zoster virus. Furthermore, Farrington, Unkel and their co-workers introduced and applied time varying

SUBMITTER: Abrams S 

PROVIDER: S-EPMC5836988 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature