DNA methylation profile in chronic myelomonocytic leukemia associates with distinct clinical, biological and genetic features.

ABSTRACT: Chromosomal abnormalities are detected in 20-30% of patients with chronic myelomonocytic leukemia (CMML) and correlate with prognosis. On the mutation level, disruptive alterations are particularly frequent in chromatin regulatory genes. However, little is known about the consequential alterations in the epigenetic marking of the genome. Here, we report the analysis of genomic DNA methylation patterns of 64 CMML patients and 10 healthy controls, using a DNA methylation microarray focused on promoter regions. Differential methylation analysis between patients and controls allowed us to identify abnormalities in DNA methylation, including hypermethylation of specific genes and large genome regions with aberrant DNA methylation. Unsupervised hierarchical cluster analysis identified two main c

SUBMITTER: Palomo L 

PROVIDER: S-EPMC5837079 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature