The SETDB2 locus: evidence for a genetic link between handedness and atopic disease.

ABSTRACT: The gene SETDB2, which mediates aspects of laterality in animal model systems, has recently been linked with human handedness as measured continuously on a scale from strong left to strong right. By contrast, it was marginally associated with a left-right dichotomous measure, and it showed no evidence of association with absolute handedness strength independent of direction. We genotyped the SETDB2 handedness-associated single nucleotide polymorphism, rs4942830, in a large healthy population likewise phenotyped for continuous, absolute, and dichotomous handedness variables. Our results demonstrated significant effects of rs4942830 genotype on continuous handedness, and weaker, marginal effects on dichotomous handedness, but no effects on absolute handedness. These results help to establish

SUBMITTER: Crespi B 

PROVIDER: S-EPMC5837111 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature