Heavier smoking increases coffee consumption: findings from a Mendelian randomization analysis.

ABSTRACT:

Background

There is evidence for a positive relationship between cigarette and coffee consumption in smokers. Cigarette smoke increases metabolism of caffeine, so this may represent a causal effect of smoking on caffeine intake.

Methods

We performed Mendelian randomization analyses in the UK Biobank (N = 114 029), the Norwegian HUNT study (N = 56 664) and the Copenhagen General Population Study (CGPS) (N = 78 650). We used the rs16969968 genetic variant as a proxy for smoking heaviness in all studies and rs4410790 and rs2472297 as proxies for coffee consumption in UK Biobank and CGPS. Analyses were conducted using linear regression and meta-analysed across studies.

Results

Each additional cigarette per day consumed by current smokers was associated with higher coffee

SUBMITTER: Bjorngaard JH 

PROVIDER: S-EPMC5837196 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature