Mammographic density defined by higher than conventional brightness thresholds better predicts breast cancer risk.

ABSTRACT:

Background

Mammographic density defined by the conventional pixel brightness threshold, and adjusted for age and body mass index (BMI), is a well-established risk factor for breast cancer. We asked if higher thresholds better separate women with and without breast cancer.

Methods

We studied Australian women, 354 with breast cancer over-sampled for early-onset and family history, and 944 unaffected controls frequency-matched for age at mammogram. We measured mammographic dense area and percent density using the CUMULUS software at the conventional threshold, which we call Cumulus , and at two increasingly higher thresholds, which we call Altocumulus and Cirrocumulus , respectively. All measures were Box-Cox transformed and adjusted for age and BMI. We estimated the odds per a

SUBMITTER: Nguyen TL 

PROVIDER: S-EPMC5837222 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature