Magnesium lactate in the treatment of Gitelman syndrome: patient-reported outcomes.

ABSTRACT:

Background

Gitelman syndrome (GS) is a rare recessively inherited renal tubulopathy associated with renal potassium (K) and magnesium (Mg) loss. It requires lifelong K and Mg supplementation at high doses that are at best unpalatable and at worst, intolerable. In particular, gastrointestinal side effects often limit full therapeutic usage.

Methods

We report here the analysis of a cohort of 28 adult patients with genetically proven GS who attend our specialist tubular disorders clinic, in whom we initiated the use of a modified-release Mg preparation (slow-release Mg lactate) and who were surveyed by questionnaire.

Results

Twenty-five patients (89%) preferred the new treatment regimen. Of these 25, 17 (68%) regarded their symptom burden as improved and seven reported n

SUBMITTER: Robinson CM 

PROVIDER: S-EPMC5837242 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature