Free-breathing liver fat quantification using a multiecho 3D stack-of-radial technique.

ABSTRACT:

Purpose

The diagnostic gold standard for nonalcoholic fatty liver disease is an invasive biopsy. Noninvasive Cartesian MRI fat quantification remains limited to a breath-hold (BH). In this work, a novel free-breathing 3D stack-of-radial (FB radial) liver fat quantification technique is developed and evaluated in a preliminary study.

Methods

Phantoms and healthy subjects (n = 11) were imaged at 3 Tesla. The proton-density fat fraction (PDFF) determined using FB radial (with and without scan acceleration) was compared to BH single-voxel MR spectroscopy (SVS) and BH 3D Cartesian MRI using linear regression (correlation coefficient ρ and concordance coefficient ρ_c ) and Bland-Altman analysis.

Results

In phantoms, PDFF showed significant correlation (ρ > 0.998,

SUBMITTER: Armstrong T 

PROVIDER: S-EPMC5837283 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature