Fetal sex-specific differences in gestational age at delivery in pre-eclampsia: a meta-analysis.

ABSTRACT:

Background

: Pre-eclampsia (PE) is a major pregnancy disorder complicating up to 8% of pregnancies. Increasing evidence indicates a sex-specific interplay between the mother, placenta and fetus. This may lead to different adaptive mechanisms during pregnancy.

Methods

We performed an individual participant data meta-analysis to determine associations of fetal sex and PE, with specific focus on gestational age at delivery in PE. This was done on 219 575 independent live-born singleton pregnancies, with a gestational age at birth between 22.0 and 43.0 weeks of gestation, from 11 studies participating in a worldwide consortium of international research groups focusing on pregnancy.

Results

Of the women, 9033 (4.1%) experienced PE in their pregnancy and 48.8% of the fetuse

SUBMITTER: Global Pregnancy Collaboration: 

PROVIDER: S-EPMC5837300 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature