Structural cerebellar correlates of cognitive and motor dysfunctions in cerebellar degeneration.

ABSTRACT: See King et al. (doi:10.1093/aww348) for a scientific commentary on this article.Detailed mapping of clinical dysfunctions to the cerebellar lobules in disease populations is necessary to establish the functional significance of lobules implicated in cognitive and motor functions in normal subjects. This study constitutes the first quantitative examination of the lobular correlates of a broad range of cognitive and motor phenomena in cerebellar disease. We analysed cross-sectional data from 72 cases with cerebellar disease and 36 controls without cerebellar disease. Cerebellar lobule volumes were derived from a graph-cut based segmentation algorithm. Sparse partial least squares, a variable selection approach, was used to identify lobules associated with motor function, language, executive

SUBMITTER: Kansal K 

PROVIDER: S-EPMC5837314 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature