The role of early life growth development, the FTO gene and exclusive breastfeeding on child BMI trajectories.

ABSTRACT:

Background

Recent studies have implicated the FTO gene in child and adult obesity. A longer duration of exclusive breastfeeding (EXBF) has been shown to reduce body mass index (BMI) and the risk of being overweight in the general population and among FTO gene carriers. However, it remains unclear whether the preventive effect of EXBF could be explained by its impact on early life growth development, e.g. ages at adiposity peak (AP) and adiposity rebound (AR) and BMI velocities in the first years of life, which are major determinants of overweight and obesity later in life.

Methods

We studied 5590 children from the British Avon Longitudinal Study of Parents and Children (ALSPAC) cohort and modelled their longitudinal BMI profiles with mixed effects models from birth to 16 yea

SUBMITTER: Wu YY 

PROVIDER: S-EPMC5837350 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature