Obesity-induced hypoadiponectinaemia: the opposite influences of central and peripheral fat compartments.

ABSTRACT:

Background and aims

The substantial reduction in adiponectin concentration among obese individuals seems to depend on fat distribution and is a marker of metabolic and adipose tissue dysfunction. We aimed to: (i) address whether abdominal fat from different compartments (visceral, deep subcutaneous abdominal and superficial subcutaneous abdominal) and gluteofemoral fat are independently associated with blood adiponectin concentration; and (ii) investigate whether abdominal (proxied by waist circumference) and gluteofemoral fat (proxied by hip circumference) accumulation causally determine blood adiponectin concentration.

Methods

To investigate the independent association of abdominal and gluteofemoral fat with adiponectin concentration, we used multivariable regression and d

SUBMITTER: Borges MC 

PROVIDER: S-EPMC5837355 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature