Tau burden and the functional connectome in Alzheimer's disease and progressive supranuclear palsy.

ABSTRACT: Alzheimer's disease and progressive supranuclear palsy (PSP) represent neurodegenerative tauopathies with predominantly cortical versus subcortical disease burden. In Alzheimer's disease, neuropathology and atrophy preferentially affect 'hub' brain regions that are densely connected. It was unclear whether hubs are differentially affected by neurodegeneration because they are more likely to receive pathological proteins that propagate trans-neuronally, in a prion-like manner, or whether they are selectively vulnerable due to a lack of local trophic factors, higher metabolic demands, or differential gene expression. We assessed the relationship between tau burden and brain functional connectivity, by combining in vivo PET imaging using the ligand AV-1451, and graph theoretic measures of res

SUBMITTER: Cope TE 

PROVIDER: S-EPMC5837359 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature