Histologic versus clinical remission in proliferative lupus nephritis.

ABSTRACT:

Background

Treatment response in lupus nephritis (LN) is defined clinically, without consideration of renal histology. Few studies have systematically examined histologic responses to induction therapy. In LN patients who underwent protocol kidney biopsies after induction immunosuppression, we describe the renal histology of the second biopsy and correlate histologic activity and damage with short- and long-term kidney outcomes.

Methods

Patients with suspected LN were biopsied for diagnosis (Biopsy 1), and those with proliferative LN were rebiopsied after induction (Biopsy 2). Histologic activity and damage at each biopsy were calculated as the National Institutes of Health activity and chronicity indices. Complete and partial renal responses after induction and after long-t

SUBMITTER: Malvar A 

PROVIDER: S-EPMC5837387 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature