Altered caudate connectivity is associated with executive dysfunction after traumatic brain injury.

ABSTRACT: Traumatic brain injury often produces executive dysfunction. This characteristic cognitive impairment often causes long-term problems with behaviour and personality. Frontal lobe injuries are associated with executive dysfunction, but it is unclear how these injuries relate to corticostriatal interactions that are known to play an important role in behavioural control. We hypothesized that executive dysfunction after traumatic brain injury would be associated with abnormal corticostriatal interactions, a question that has not previously been investigated. We used structural and functional MRI measures of connectivity to investigate this. Corticostriatal functional connectivity in healthy individuals was initially defined using a data-driven approach. A constrained independent component ana

SUBMITTER: De Simoni S 

PROVIDER: S-EPMC5837394 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature