Power calculator for instrumental variable analysis in pharmacoepidemiology.

ABSTRACT:

Background

Instrumental variable analysis, for example with physicians' prescribing preferences as an instrument for medications issued in primary care, is an increasingly popular method in the field of pharmacoepidemiology. Existing power calculators for studies using instrumental variable analysis, such as Mendelian randomization power calculators, do not allow for the structure of research questions in this field. This is because the analysis in pharmacoepidemiology will typically have stronger instruments and detect larger causal effects than in other fields. Consequently, there is a need for dedicated power calculators for pharmacoepidemiological research.

Methods and results

The formula for calculating the power of a study using instrumental variable analysis in the co

SUBMITTER: Walker VM 

PROVIDER: S-EPMC5837396 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature