Spike-related haemodynamic responses overlap with high frequency oscillations in patients with focal epilepsy.

ABSTRACT: Simultaneous scalp EEG/functional MRI measures non-invasively haemodynamic responses to interictal epileptic discharges, which are related to the epileptogenic zone. High frequency oscillations are also an excellent indicator of this zone, but are primarily recorded from intracerebral EEG. We studied the spatial overlap of these two important markers in patients with drug-resistant epilepsy to assess if their combination could help better define the extent of the epileptogenic zone. We included patients who underwent EEG-functional MRI and later intracerebral EEG. Based on intracerebral EEG findings, we separated patients with unifocal seizures from patients with multifocal or unknown onset seizures. Haemodynamic t-maps were coregistered with the intracerebral electrode positions. Each EEG

SUBMITTER: Gonzalez Otarula KA 

PROVIDER: S-EPMC5837415 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature