A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy.

ABSTRACT:

Background

Inheritance of apolipoprotein L1 gene (APOL1) renal-risk variants in a recessive pattern strongly associates with non-diabetic end-stage kidney disease (ESKD). Further evidence supports risk modifiers in APOL1-associated nephropathy; some studies demonstrate that heterozygotes possess excess risk for ESKD or show earlier age at ESKD, relative to those with zero risk alleles. Nearby loci are also associated with ESKD in non-African Americans.

Methods

We assessed the role of the APOL3 null allele rs11089781 on risk of non-diabetic ESKD. Four cohorts containing 2781 ESKD cases and 2474 controls were analyzed.

Results

Stratifying by APOL1 risk genotype (recessive) and adjusting for African ancestry identified a significant additive association between rs1108978

SUBMITTER: Skorecki KL 

PROVIDER: S-EPMC5837424 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature