Editor's Highlight: Genetic Targets of Acute Toluene Inhalation in Drosophila melanogaster.

ABSTRACT: Interpretation and use of data from high-throughput assays for chemical toxicity require links between effects at molecular targets and adverse outcomes in whole animals. The well-characterized genome of Drosophila melanogaster provides a potential model system by which phenotypic responses to chemicals can be mapped to genes associated with those responses, which may in turn suggest adverse outcome pathways associated with those genes. To determine the utility of this approach, we used the Drosophila Genetics Reference Panel (DGRP), a collection of ∼200 homozygous lines of fruit flies whose genomes have been sequenced. We quantified toluene-induced suppression of motor activity in 123 lines of these flies during exposure to toluene, a volatile organic compound known to induce narcosis in

SUBMITTER: Bushnell PJ 

PROVIDER: S-EPMC5837442 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature