Dynamics of convulsive seizure termination and postictal generalized EEG suppression.

ABSTRACT: It is not fully understood how seizures terminate and why some seizures are followed by a period of complete brain activity suppression, postictal generalized EEG suppression. This is clinically relevant as there is a potential association between postictal generalized EEG suppression, cardiorespiratory arrest and sudden death following a seizure. We combined human encephalographic seizure data with data of a computational model of seizures to elucidate the neuronal network dynamics underlying seizure termination and the postictal generalized EEG suppression state. A multi-unit computational neural mass model of epileptic seizure termination and postictal recovery was developed. The model provided three predictions that were validated in EEG recordings of 48 convulsive seizures from 48 sub

SUBMITTER: Bauer PR 

PROVIDER: S-EPMC5837448 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature