Altered circadian hemodynamic and renal function in cirrhosis.

ABSTRACT:

Background

Given that alterations in systemic hemodynamics have a profound influence on renal function in patients with cirrhosis, it is surprising that circadian variations in blood pressure (BP) and renal electrolyte excretion have scarcely been studied. Our aims were to define the relationship of 24-h ambulatory BP changes with renal tubular function and to determine the influence of endotoxemia on BP and urinary parameters.

Methods

Forty healthy controls served as a comparator to 20 cirrhotic patients. They underwent 24-h ambulatory BP monitoring and 24-h urine collection.

Results

Subjects with cirrhosis demonstrated significant diurnal variations in urinary excretion of sodium (57.7 µmol/min day versus 87 µmol/min night) and creatinine (826 µg/min day versus 1202

SUBMITTER: Liangpunsakul S 

PROVIDER: S-EPMC5837480 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature