Estimating glomerular filtration rate for the full age spectrum from serum creatinine and cystatin C.

ABSTRACT:

Background

We recently published and validated the new serum creatinine (Scr)-based full-age-spectrum equation (FAS crea ) for estimating the glomerular filtration rate (GFR) for healthy and kidney-diseased subjects of all ages. The equation was based on the concept of normalized Scr and shows equivalent to superior prediction performance to the currently recommended equations for children, adolescents, adults and older adults.

Methods

Based on an evaluation of the serum cystatin C (ScysC) distribution, we defined normalization constants for ScysC ( Q cysC  =   0.82 mg/L for ages <70 years and Q cysC  =   0.95 mg/L for ages ≥70 years). By replacing Scr/ Q crea in the FAS crea equation with ScysC/ Q cysC , or with the average of both normalized biomarkers, we obtained new Scy

SUBMITTER: Pottel H 

PROVIDER: S-EPMC5837496 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature