Associations of dysnatremias with mortality in chronic kidney disease.

ABSTRACT:

Background

Hyponatremia and hypernatremia are associated with death in the general population and those with chronic kidney disease (CKD). We studied the associations between dysnatremias, all-cause mortality and causes of death in a large cohort of Stage 3 and 4 CKD patients.

Methods

We included 45 333 patients with Stage 3 and 4 CKDs followed in a large healthcare system. Associations between hyponatremia (<136 mmol/L) and hypernatremia (>145), and all-cause mortality and causes of death (cardiovascular, malignancy related and non-cardiovascular/non-malignancy related) were studied using Cox proportional hazards and competing risk models.

Results

Dysnatremias were found in 9.2% of the study population. In separate multivariable Cox proportional hazards models using

SUBMITTER: Huang H 

PROVIDER: S-EPMC5837502 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature