Altered sleep homeostasis correlates with cognitive impairment in patients with focal epilepsy.

ABSTRACT: In animal studies, both seizures and interictal spikes induce synaptic potentiation. Recent evidence suggests that electroencephalogram slow wave activity during sleep reflects synaptic potentiation during wake, and that its homeostatic decrease during the night is associated with synaptic renormalization and its beneficial effects. Here we asked whether epileptic activity induces plastic changes that can be revealed by high-density electroencephalography recordings during sleep in 15 patients with focal epilepsy and 15 control subjects. Compared to controls, patients with epilepsy displayed increased slow wave activity power during non-rapid eye movement sleep over widespread, bilateral scalp regions. This global increase in slow wave activity power was positively correlated with the freq

SUBMITTER: Boly M 

PROVIDER: S-EPMC5837505 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature