Dietary glutamine, glutamate and mortality: two large prospective studies in US men and women.

ABSTRACT:

Background

Emerging studies have related circulating glutamine metabolites to various chronic diseases such as cardiovascular disease and cancer; diet is the major source of nutrients involved in glutamine metabolism. However, it remains unknown whether dietary intakes of glutamine, glutamate,and their ratio are related to total and cause-specific mortality.

Methods

We followed 74 082 women from the Nurses' Health Study (1984-2012) and 42 303 men from the Health Professionals Follow-up Study (1986-2012), who were free of cardiovascular disease and cancer at baseline. Diet was updated every 2 to 4 years by using validated food frequency questionnaires. The content of glutamine and glutamate in foods was calculated based on protein fractions generated from gene sequencing meth

SUBMITTER: Ma W 

PROVIDER: S-EPMC5837531 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature