Creatinine generation from kinetic modeling with or without postdialysis serum creatinine measurement: results from the HEMO study.

ABSTRACT:

Background

A convenient method to estimate the creatinine generation rate and measures of creatinine clearance in hemodialysis patients using formal kinetic modeling and standard pre- and postdialysis blood samples has not been described.

Methods

We used data from 366 dialysis sessions characterized during follow-up month 4 of the HEMO study, during which cross-dialyzer clearances for both urea and creatinine were available. Blood samples taken at 1 h into dialysis and 30 min and 60 min after dialysis were used to determine how well a two-pool kinetic model could predict creatinine concentrations and other kinetic parameters, including the creatinine generation rate. An extrarenal creatinine clearance of 0.038 l/kg/24 h was included in the model.

Results

Diffusive cro

SUBMITTER: Daugirdas JT 

PROVIDER: S-EPMC5837547 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature