Genetically low vitamin D concentrations and myopic refractive error: a Mendelian randomization study.

ABSTRACT:

Background

Myopia prevalence has increased in the past 20 years, with many studies linking the increase to reduced time spent outdoors. A number of recent observational studies have shown an inverse association between vitamin D [25(OH)D] serum levels and myopia. However, in such studies it is difficult to separate the effects of time outdoors and vitamin D levels. In this work we use Mendelian randomization (MR) to assess if genetically determined 25(OH)D levels contribute to the degree of myopia.

Methods

We performed MR using results from a meta-analysis of refractive error (RE) genome-wide association study (GWAS) that included 37 382 and 8 376 adult participants of European and Asian ancestry, respectively, published by the Consortium for Refractive Error And Myopia (CRE

SUBMITTER: Cuellar-Partida G 

PROVIDER: S-EPMC5837568 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature