Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults.

ABSTRACT:

Background

Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes in blood lipids.

Methods

Participants from the GLACIER Study (Nmax = 3492) were genotyped with the MetaboChip array, from which 29 387 SNPs (single nucleotide polymorphisms; replication, fine-mapping regions and wildcard SNPs for lipid traits) were extracted for association tests with 10-year change in total cholesterol (ΔTC) and triglycerides (ΔTG). Four additional prospective cohort studies (MDC, PIVUS, ULSAM, MRC Ely; Nmax = 8263 participants) were used for replication. We conducted an in silico look-up for association with coronary artery disease (C

SUBMITTER: Varga TV 

PROVIDER: S-EPMC5837581 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature